Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 11/23/21 5:45 PM | 11/23/21 5:45 PM | Dynamo Kiew | FC Bayern Munich | Group E | 1-2 | 10 - 10 - 3 |
| 11/23/21 5:50 PM | 11/23/21 5:50 PM | FC Villarreal | Manchester United | Group F | 0-2 | 6 - 5 - 5 |
| 11/23/21 8:00 PM | 11/23/21 8:00 PM | Malmö FF | Zenit St. Petersburg | Group H | 1-1 | 9 - 7 - 4 |
| 11/23/21 8:00 PM | 11/23/21 8:00 PM | Chelsea FC | Juventus Turin | Group H | 4-0 | 3 - 7 - 10 |
| 11/23/21 8:00 PM | 11/23/21 8:00 PM | Young Boys Bern | Atalanta Bergamo | Group F | 3-3 | 10 - 9 - 3 |
| 11/23/21 8:00 PM | 11/23/21 8:00 PM | FC Sevilla | VfL Wolfsburg | Group G | 2-0 | 3 - 7 - 10 |
| 11/23/21 8:00 PM | 11/23/21 8:00 PM | OSC Lille | FC Red Bull Salzburg | Group G | 1-0 | 4 - 6 - 8 |
| 11/23/21 8:00 PM | 11/23/21 8:00 PM | FC Barcelona | Benfica Lisbon | Group E | 0-0 | 3 - 9 - 10 |
| 11/24/21 5:45 PM | 11/24/21 5:45 PM | Inter Milan | Schachtjor Donezk | Group D | 2-0 | 3 - 10 - 10 |
| 11/24/21 5:45 PM | 11/24/21 5:45 PM | Besiktas Istanbul | Ajax Amsterdam | Group C | 1-2 | 10 - 9 - 3 |
| 11/24/21 8:00 PM | 11/24/21 8:00 PM | Sheriff Tiraspol | Real Madrid | Group D | 0-3 | 10 - 10 - 3 |
| 11/24/21 8:00 PM | 11/24/21 8:00 PM | Atletico Madrid | AC Milan | Group B | 0-1 | 3 - 6 - 10 |
| 11/24/21 8:00 PM | 11/24/21 8:00 PM | Liverpool FC | FC Porto | Group B | 2-0 | 3 - 10 - 10 |
| 11/24/21 8:00 PM | 11/24/21 8:00 PM | Manchester City | Paris St. Germain | Group A | 2-1 | 4 - 5 - 7 |
| 11/24/21 8:00 PM | 11/24/21 8:00 PM | Club Brugge | RB Leipzig | Group A | 0-5 | 7 - 5 - 4 |
| 11/24/21 8:00 PM | 11/24/21 8:00 PM | Sporting Lisbon | Borussia Dortmund | Group C | 3-1 | 6 - 6 - 4 |