Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 9/28/21 11:45 AM | 9/28/21 11:45 AM | Schachtjor Donezk | Inter Milan | Group D | 0-0 | 2 - 4 points |
| 9/28/21 11:45 AM | 9/28/21 11:45 AM | Ajax Amsterdam | Besiktas Istanbul | Group C | 2-0 | 2 - 4 points |
| 9/28/21 2:00 PM | 9/28/21 2:00 PM | Real Madrid | Sheriff Tiraspol | Group D | 1-2 | 2 - 4 points |
| 9/28/21 2:00 PM | 9/28/21 2:00 PM | FC Porto | Liverpool FC | Group B | 1-5 | 4 - 8 points |
| 9/28/21 2:00 PM | 9/28/21 2:00 PM | AC Milan | Atletico Madrid | Group B | 1-2 | 2 - 4 points |
| 9/28/21 2:00 PM | 9/28/21 2:00 PM | RB Leipzig | Club Brugge | Group A | 1-2 | 2 - 4 points |
| 9/28/21 2:00 PM | 9/28/21 2:00 PM | Paris St. Germain | Manchester City | Group A | 2-0 | 2 - 4 points |
| 9/28/21 2:00 PM | 9/28/21 2:00 PM | Borussia Dortmund | Sporting Lisbon | Group C | 1-0 | 2 - 4 points |
| 9/29/21 11:45 AM | 9/29/21 11:45 AM | Zenit St. Petersburg | Malmö FF | Group H | 4-0 | 2 - 4 points |
| 9/29/21 11:45 AM | 9/29/21 11:45 AM | Atalanta Bergamo | Young Boys Bern | Group F | 1-0 | 2 - 4 points |
| 9/29/21 2:00 PM | 9/29/21 2:00 PM | Juventus Turin | Chelsea FC | Group H | 1-0 | 2 - 4 points |
| 9/29/21 2:00 PM | 9/29/21 2:00 PM | VfL Wolfsburg | FC Sevilla | Group G | 1-1 | 2 - 4 points |
| 9/29/21 2:00 PM | 9/29/21 2:00 PM | FC Red Bull Salzburg | OSC Lille | Group G | 2-1 | 2 - 4 points |
| 9/29/21 2:00 PM | 9/29/21 2:00 PM | Benfica Lisbon | FC Barcelona | Group E | 3-0 | 2 - 4 points |
| 9/29/21 2:00 PM | 9/29/21 2:00 PM | FC Bayern Munich | Dynamo Kiew | Group E | 5-0 | 2 - 4 points |
| 9/29/21 2:00 PM | 9/29/21 2:00 PM | Manchester United | FC Villarreal | Group F | 2-1 | 2 - 4 points |