Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 12/7/21 11:45 AM | 12/7/21 11:45 AM | RB Leipzig | Manchester City | Group A | 2-1 | 2 - 4 points |
| 12/7/21 11:45 AM | 12/7/21 11:45 AM | Paris St. Germain | Club Brugge | Group A | 4-1 | 2 - 4 points |
| 12/7/21 2:00 PM | 12/7/21 2:00 PM | Schachtjor Donezk | Sheriff Tiraspol | Group D | 1-1 | 2 - 4 points |
| 12/7/21 2:00 PM | 12/7/21 2:00 PM | Real Madrid | Inter Milan | Group D | 2-0 | 2 - 4 points |
| 12/7/21 2:00 PM | 12/7/21 2:00 PM | FC Porto | Atletico Madrid | Group B | 1-3 | 2 - 4 points |
| 12/7/21 2:00 PM | 12/7/21 2:00 PM | AC Milan | Liverpool FC | Group B | 1-2 | 4 - 8 points |
| 12/7/21 2:00 PM | 12/7/21 2:00 PM | Borussia Dortmund | Besiktas Istanbul | Group C | 5-0 | 2 - 4 points |
| 12/7/21 2:00 PM | 12/7/21 2:00 PM | Ajax Amsterdam | Sporting Lisbon | Group C | 4-2 | 2 - 4 points |
| 12/8/21 11:45 AM | 12/8/21 11:45 AM | Juventus Turin | Malmö FF | Group H | 1-0 | 2 - 4 points |
| 12/8/21 11:45 AM | 12/8/21 11:45 AM | Zenit St. Petersburg | Chelsea FC | Group H | 3-3 | 2 - 4 points |
| 12/8/21 2:00 PM | 12/8/21 2:00 PM | Manchester United | Young Boys Bern | Group F | 1-1 | 2 - 4 points |
| 12/8/21 2:00 PM | 12/8/21 2:00 PM | FC Red Bull Salzburg | FC Sevilla | Group G | 1-0 | 2 - 4 points |
| 12/8/21 2:00 PM | 12/8/21 2:00 PM | VfL Wolfsburg | OSC Lille | Group G | 1-3 | 2 - 4 points |
| 12/8/21 2:00 PM | 12/8/21 2:00 PM | Benfica Lisbon | Dynamo Kiew | Group E | 2-0 | 2 - 4 points |
| 12/8/21 2:00 PM | 12/8/21 2:00 PM | FC Bayern Munich | FC Barcelona | Group E | 3-0 | 2 - 4 points |
| 12/9/21 12:00 PM | 12/9/21 12:00 PM | Atalanta Bergamo | FC Villarreal | Group F | 2-3 | 2 - 4 points |