| Date | Home | Away | Result |
|---|---|---|---|
| 8/5/22 10:45 AM | Cagliari Calcio | AC Perugia | 3-2 |
| 8/5/22 11:00 AM | Udinese Calcio | AC Feralpi Salo | 2-1 |
| 8/5/22 2:00 PM | US Lecce | AS Cittadella | 2-3a.e.t/1-1FT |
| 8/5/22 2:15 PM | Sampdoria Genua | Reggina 1914 | 1-0 |
| 8/6/22 10:45 AM | AC Pisa | Brescia Calcio | 1-4 |
| 8/6/22 11:00 AM | Spezia Calcio | Como Calcio | 5-1 |
| 8/6/22 2:00 PM | FC Empoli | SPAL Ferrara | 1-2a.e.t/1-1FT |
| 8/6/22 2:15 PM | FC Turin | Palermo FC | 3-0 |
| 8/7/22 10:45 AM | FC Venice | Ascoli Calcio | 2-3 |
| 8/7/22 11:00 AM | Hellas Verona | SSC Bari | 1-4 |
| 8/7/22 2:00 PM | US Salernitana | Parma Calcio 1913 | 0-2 |
| 8/7/22 2:15 PM | AC Monza | Frosinone Calcio | 3-2 |
| 8/8/22 10:45 AM | FC Genua 1893 | Benevento Calcio | 3-2 |
| 8/8/22 11:00 AM | Modena FC | Sassuolo Calcio | 3-2 |
| 8/8/22 2:00 PM | US Cremonese | Ternana Calcio | 3-2 |
| 8/8/22 2:15 PM | FC Bologna | Cosenza Calcio | 1-0 |