| Date | Home | Away | Result |
|---|---|---|---|
| 10/18/22 11:00 AM | FC Genua 1893 | SPAL Ferrara | 1-0 |
| 10/18/22 2:00 PM | FC Turin | AS Cittadella | 4-0 |
| 10/19/22 8:00 AM | Spezia Calcio | Brescia Calcio | 3-1 |
| 10/19/22 11:00 AM | Parma Calcio 1913 | SSC Bari | 1-0 |
| 10/19/22 2:00 PM | Udinese Calcio | AC Monza | 2-3 |
| 10/20/22 8:00 AM | US Cremonese | Modena FC | 4-2a.e.t/2-2FT |
| 10/20/22 11:00 AM | Sampdoria Genua | Ascoli Calcio | 11-10a.PSO/1-1FT |
| 10/20/22 2:00 PM | FC Bologna | Cagliari Calcio | 1-0 |