Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/22/21 2:00 PM | 10/22/21 2:00 PM | CA Osasuna | FC Granada | 1-1 | 2 - 5 points |
| 10/23/21 7:00 AM | 10/23/21 7:00 AM | FC Valencia | RCD Mallorca | 2-2 | 2 - 5 points |
| 10/23/21 9:15 AM | 10/23/21 9:15 AM | FC Cadiz | Deportivo Alaves | 0-2 | 2 - 5 points |
| 10/23/21 11:30 AM | 10/23/21 11:30 AM | FC Elche | Espanyol Barcelona | 2-2 | 2 - 5 points |
| 10/23/21 2:00 PM | 10/23/21 2:00 PM | Athletic Bilbao | FC Villarreal | 2-1 | 2 - 5 points |
| 10/24/21 7:00 AM | 10/24/21 7:00 AM | FC Sevilla | UD Levante | 5-3 | 2 - 5 points |
| 10/24/21 9:15 AM | 10/24/21 9:15 AM | FC Barcelona | Real Madrid | 1-2 | 2 - 5 points |
| 10/24/21 11:30 AM | 10/24/21 11:30 AM | Real Betis Sevilla | Rayo Vallecano | 3-2 | 2 - 5 points |
| 10/24/21 2:00 PM | 10/24/21 2:00 PM | Atletico Madrid | Real Sociedad | 2-2 | 2 - 5 points |
| 10/25/21 2:00 PM | 10/25/21 2:00 PM | FC Getafe | Celta Vigo | 0-3 | 2 - 5 points |