Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 1/8/22 7:00 AM | 1/8/22 7:00 AM | UD Levante | RCD Mallorca | 2-0 | 2 - 5 points |
| 1/8/22 9:15 AM | 1/8/22 9:15 AM | Real Sociedad | Celta Vigo | 1-0 | 2 - 5 points |
| 1/8/22 11:30 AM | 1/8/22 11:30 AM | FC Granada | FC Barcelona | 1-1 | 2 - 5 points |
| 1/8/22 2:00 PM | 1/8/22 2:00 PM | Real Madrid | FC Valencia | 4-1 | 2 - 5 points |
| 1/9/22 7:00 AM | 1/9/22 7:00 AM | Rayo Vallecano | Real Betis Sevilla | 1-1 | 2 - 5 points |
| 1/9/22 9:15 AM | 1/9/22 9:15 AM | FC Sevilla | FC Getafe | 1-0 | 2 - 5 points |
| 1/9/22 11:30 AM | 1/9/22 11:30 AM | CA Osasuna | FC Cadiz | 2-0 | 2 - 5 points |
| 1/9/22 11:30 AM | 1/9/22 11:30 AM | Deportivo Alaves | Athletic Bilbao | 0-0 | 2 - 5 points |
| 1/9/22 2:00 PM | 1/9/22 2:00 PM | FC Villarreal | Atletico Madrid | 2-2 | 2 - 5 points |
| 1/10/22 2:00 PM | 1/10/22 2:00 PM | Espanyol Barcelona | FC Elche | 1-2 | 2 - 5 points |