Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/15/22 2:00 PM | 4/15/22 2:00 PM | Real Sociedad | Real Betis Sevilla | 0-0 | 2 - 5 points |
| 4/16/22 7:00 AM | 4/16/22 7:00 AM | FC Elche | RCD Mallorca | 3-0 | 2 - 5 points |
| 4/16/22 9:15 AM | 4/16/22 9:15 AM | Deportivo Alaves | Rayo Vallecano | 1-0 | 2 - 5 points |
| 4/16/22 11:30 AM | 4/16/22 11:30 AM | FC Valencia | CA Osasuna | 1-2 | 2 - 5 points |
| 4/16/22 2:00 PM | 4/16/22 2:00 PM | FC Getafe | FC Villarreal | 1-2 | 2 - 5 points |
| 4/17/22 7:00 AM | 4/17/22 7:00 AM | FC Granada | UD Levante | 1-4 | 2 - 5 points |
| 4/17/22 9:15 AM | 4/17/22 9:15 AM | Atletico Madrid | Espanyol Barcelona | 2-1 | 2 - 5 points |
| 4/17/22 11:30 AM | 4/17/22 11:30 AM | Athletic Bilbao | Celta Vigo | 0-2 | 2 - 5 points |
| 4/17/22 2:00 PM | 4/17/22 2:00 PM | FC Sevilla | Real Madrid | 2-3 | 2 - 5 points |
| 4/18/22 2:00 PM | 4/18/22 2:00 PM | FC Barcelona | FC Cadiz | 0-1 | 2 - 5 points |