Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 4/29/22 2:00 PM | 4/29/22 2:00 PM | FC Sevilla | FC Cadiz | 1-1 | 2 - 5 points |
| 4/30/22 7:00 AM | 4/30/22 7:00 AM | Deportivo Alaves | FC Villarreal | 2-1 | 2 - 5 points |
| 4/30/22 9:15 AM | 4/30/22 9:15 AM | Real Madrid | Espanyol Barcelona | 4-0 | 2 - 5 points |
| 4/30/22 11:30 AM | 4/30/22 11:30 AM | FC Valencia | UD Levante | 1-1 | 2 - 5 points |
| 4/30/22 2:00 PM | 4/30/22 2:00 PM | Athletic Bilbao | Atletico Madrid | 2-0 | 2 - 5 points |
| 5/1/22 7:00 AM | 5/1/22 7:00 AM | FC Elche | CA Osasuna | 1-1 | 2 - 5 points |
| 5/1/22 9:15 AM | 5/1/22 9:15 AM | FC Granada | Celta Vigo | 1-1 | 2 - 5 points |
| 5/1/22 11:30 AM | 5/1/22 11:30 AM | Rayo Vallecano | Real Sociedad | 1-1 | 2 - 5 points |
| 5/1/22 2:00 PM | 5/1/22 2:00 PM | FC Barcelona | RCD Mallorca | 2-1 | 2 - 5 points |
| 5/2/22 2:00 PM | 5/2/22 2:00 PM | FC Getafe | Real Betis Sevilla | 0-0 | 2 - 5 points |