Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/17/21 2:00 PM | 9/17/21 2:00 PM | Celta Vigo | FC Cadiz | 1-2 | 2 - 5 points |
| 9/18/21 7:00 AM | 9/18/21 7:00 AM | Rayo Vallecano | FC Getafe | 3-0 | 2 - 5 points |
| 9/18/21 9:15 AM | 9/18/21 9:15 AM | Atletico Madrid | Athletic Bilbao | 0-0 | 2 - 5 points |
| 9/18/21 11:30 AM | 9/18/21 11:30 AM | FC Elche | UD Levante | 1-1 | 2 - 5 points |
| 9/18/21 2:00 PM | 9/18/21 2:00 PM | Deportivo Alaves | CA Osasuna | 0-2 | 2 - 5 points |
| 9/19/21 7:00 AM | 9/19/21 7:00 AM | RCD Mallorca | FC Villarreal | 0-0 | 2 - 5 points |
| 9/19/21 9:15 AM | 9/19/21 9:15 AM | Real Sociedad | FC Sevilla | 0-0 | 2 - 5 points |
| 9/19/21 11:30 AM | 9/19/21 11:30 AM | Real Betis Sevilla | Espanyol Barcelona | 2-2 | 2 - 5 points |
| 9/19/21 2:00 PM | 9/19/21 2:00 PM | FC Valencia | Real Madrid | 1-2 | 2 - 5 points |
| 9/20/21 2:00 PM | 9/20/21 2:00 PM | FC Barcelona | FC Granada | 1-1 | 2 - 5 points |