Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/21/21 12:30 PM | 9/21/21 12:30 PM | FC Getafe | Atletico Madrid | 1-2 | 2 - 5 points |
| 9/21/21 3:00 PM | 9/21/21 3:00 PM | Athletic Bilbao | Rayo Vallecano | 1-2 | 2 - 5 points |
| 9/21/21 3:00 PM | 9/21/21 3:00 PM | UD Levante | Celta Vigo | 0-2 | 2 - 5 points |
| 9/22/21 12:30 PM | 9/22/21 12:30 PM | Espanyol Barcelona | Deportivo Alaves | 1-0 | 2 - 5 points |
| 9/22/21 12:30 PM | 9/22/21 12:30 PM | FC Sevilla | FC Valencia | 3-1 | 2 - 5 points |
| 9/22/21 3:00 PM | 9/22/21 3:00 PM | Real Madrid | RCD Mallorca | 6-1 | 2 - 5 points |
| 9/22/21 3:00 PM | 9/22/21 3:00 PM | FC Villarreal | FC Elche | 4-1 | 2 - 5 points |
| 9/23/21 12:30 PM | 9/23/21 12:30 PM | FC Granada | Real Sociedad | 2-3 | 2 - 5 points |
| 9/23/21 12:30 PM | 9/23/21 12:30 PM | CA Osasuna | Real Betis Sevilla | 1-3 | 2 - 5 points |
| 9/23/21 3:00 PM | 9/23/21 3:00 PM | FC Cadiz | FC Barcelona | 0-0 | 2 - 5 points |