Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/20/21 6:30 PM | 8/20/21 6:30 PM | RB Leipzig | VfB Stuttgart | 4-0 | 3 - 8 - 9 |
| 8/21/21 1:30 PM | 8/21/21 1:30 PM | SpVgg Greuther Fürth | Arminia Bielefeld | 1-1 | 6 - 4 - 5 |
| 8/21/21 1:30 PM | 8/21/21 1:30 PM | VfL Bochum | FSV Mainz 05 | 2-0 | 7 - 6 - 4 |
| 8/21/21 1:30 PM | 8/21/21 1:30 PM | SC Freiburg | Borussia Dortmund | 2-1 | 9 - 8 - 3 |
| 8/21/21 1:30 PM | 8/21/21 1:30 PM | Eintracht Frankfurt | FC Augsburg | 0-0 | 3 - 7 - 9 |
| 8/21/21 1:35 PM | 8/21/21 1:35 PM | Hertha BSC | VfL Wolfsburg | 1-2 | 9 - 6 - 4 |
| 8/21/21 4:30 PM | 8/21/21 4:30 PM | Bayer 04 Leverkusen | Bor. Mönchengladbach | 4-0 | 5 - 5 - 5 |
| 8/22/21 1:30 PM | 8/22/21 1:30 PM | 1899 Hoffenheim | 1. FC Union Berlin | 2-2 | 3 - 8 - 9 |
| 8/22/21 3:30 PM | 8/22/21 3:30 PM | FC Bayern Munich | 1. FC Köln | 3-2 | 3 - 9 - 9 |