| 12/15/20 11:00 AM | CA Pulpileno | CD Lugo | 1-2 |
| 12/15/20 12:00 PM | CD Marchamalo | SD Huesca | 2-3a.e.t |
| 12/15/20 12:00 PM | UD Tomares | CA Osasuna | 0-6 |
| 12/15/20 12:00 PM | CD Cantolagua | Real Valladolid | 0-5 |
| 12/15/20 12:00 PM | Sestao River Club | CD Teneriffa | 0-2a.e.t |
| 12/15/20 12:00 PM | Club Portugalete | SD Ponferradina | 1-0 |
| 12/15/20 1:00 PM | CF Lucena | FC Sevilla | 0-3 |
| 12/15/20 1:00 PM | CF Ourense | CD Leganes | 0-1a.e.t |
| 12/15/20 1:30 PM | CD Coria | Real Oviedo | 2-3 |
| 12/16/20 8:15 AM | FC Coruxo | FC Malaga | 0-4 |
| 12/16/20 8:30 AM | CD Lealtad de Villaviciosa | AD Alcorcon | 1-2 |
| 12/16/20 9:00 AM | Burgos CF | Andorra CF | 2-0 |
| 12/16/20 11:00 AM | CD Quintanar del Rey | Sporting Gijon | 1-2 |
| 12/16/20 11:00 AM | CE L'Hospitalet | UD Almeria | 1-4 |
| 12/16/20 11:00 AM | CD San Fernando | CD Castellon | 0-2 |
| 12/16/20 11:00 AM | Cordoba CF | Albacete Balompie | 1-0 |
| 12/16/20 11:30 AM | CD Numancia | Lorca Deportiva CF | 4-1 |
| 12/16/20 12:00 PM | Racing Murcia | UD Levante | 0-5 |
| 12/16/20 12:00 PM | CD Cardassar | Atletico Madrid | 0-3 |
| 12/16/20 12:00 PM | CF Terrassa | FC Valencia | 2-4a.e.t |
| 12/16/20 12:00 PM | Las Rozas CF | CD Mirandes | 1-0 |
| 12/16/20 12:00 PM | Gimnastica de Torrelavega | Real Saragossa | 0-2a.e.t |
| 12/16/20 12:00 PM | UE Llagostera | Espanyol Barcelona | 0-1a.e.t |
| 12/16/20 12:00 PM | CD Ibiza Islas Pitiusas | CD Sabadell | 0-2 |
| 12/16/20 12:00 PM | Atletico Baleares | CF Fuenlabrada | 0-1 |
| 12/16/20 12:00 PM | SD Amorebieta | UD Logrones | 1-0 |
| 12/16/20 12:00 PM | Sadcf Internacional De Madrid Dsl | Linares Deportivo | 0-3 |
| 12/16/20 12:30 PM | CD Guijuelo | RCD Mallorca | 0-1 |
| 12/16/20 12:30 PM | CF Rayo Majadahonda | Yeclano Deportivo | 1-2a.e.t |
| 12/16/20 1:00 PM | Marbella FC | Club Lleida Esportiu | 1-0a.e.t |
| 12/16/20 1:30 PM | CD Calahorra | CF La Nucia | 0-1 |
| 12/16/20 2:00 PM | CD Bunol | FC Elche | 1-2 |
| 12/16/20 2:00 PM | CD Rincon | Deportivo Alaves | 0-2 |
| 12/16/20 2:00 PM | SD Leioa | FC Villarreal | 0-6 |
| 12/16/20 4:30 PM | CD Marino | UE Cornella | 0-1 |
| 12/17/20 10:00 AM | Deportivo La Coruna | CD El Ejido | 1-0 |
| 12/17/20 11:00 AM | CD Artistico Navalcarnero | CD Badajoz | 1-0 |
| 12/17/20 12:00 PM | CD Anaitasuna | FC Getafe | 1-2 |
| 12/17/20 12:00 PM | CD Ribadumia | FC Cadiz | 0-2 |
| 12/17/20 12:00 PM | AD San Juan | FC Granada | 0-2 |
| 12/17/20 12:00 PM | Gimnastica Segoviana | FC Girona | 0-2 |
| 12/17/20 12:00 PM | CD Teruel | Rayo Vallecano | 2-3a.e.t |
| 12/17/20 12:00 PM | UD Ibiza Eivissa | SD Compostela | 2-1a.e.t |
| 12/17/20 12:00 PM | Cultural y Deportiva Leonesa | CF Villanovense | 1-0 |
| 12/17/20 12:00 PM | Union Mutilvera | Racing Santander | 1-0 |
| 12/17/20 12:30 PM | UCAM Murcia | Real Betis Sevilla | 0-2 |
| 12/17/20 12:30 PM | Deportiva Santa Eulalia del Rio | SD Tarazona | 4-1 |
| 12/17/20 1:00 PM | CD Varea | UD Las Palmas | 0-4 |
| 12/17/20 1:00 PM | CF Pontevedra | FC Cartagena | 2-1 |
| 12/17/20 1:15 PM | CD Alcoyano | CD Laredo | 4-1 |
| 12/17/20 1:30 PM | UD Extremadura | UD Socuellamos | 1-2 |
| 12/17/20 2:00 PM | Racing Rioja | SD Eibar | 0-2 |
| 12/17/20 2:00 PM | UD Llanera | Celta Vigo | 0-5 |
| 12/23/20 11:30 AM | Club Haro Deportivo | Linense | 2-1 |
| 12/23/20 12:00 PM | Zamora CF | SD Logrones | 2-1 |
| 12/30/20 5:00 AM | UD Poblense | Olot | 1-2 |
