| Date | Home | Away | Result |
|---|---|---|---|
| 1/16/21 5:00 AM | UD Almeria | Deportivo Alaves | 5-0 |
| 1/16/21 5:00 AM | Deportiva Santa Eulalia del Rio | Real Valladolid | 1-4a.e.t |
| 1/16/21 9:00 AM | FC Girona | FC Cadiz | 2-0 |
| 1/16/21 11:00 AM | CF Fuenlabrada | UD Levante | 3-5a.PSO |
| 1/16/21 1:00 PM | CD Leganes | FC Sevilla | 0-1a.e.t |
| 1/16/21 3:00 PM | Rayo Vallecano | FC Elche | 2-0 |
| 1/17/21 5:00 AM | FC Malaga | FC Granada | 1-2 |
| 1/17/21 5:00 AM | Espanyol Barcelona | CA Osasuna | 0-2 |
| 1/17/21 9:00 AM | Sporting Gijon | Real Betis Sevilla | 0-2 |
| 1/17/21 9:00 AM | CD Artistico Navalcarnero | SD Eibar | 3-1 |
| 1/17/21 11:00 AM | AD Alcorcon | FC Valencia | 0-2 |
| 1/17/21 11:00 AM | CD Teneriffa | FC Villarreal | 0-1 |
| 1/20/21 12:00 PM | Cordoba CF | Real Sociedad | 0-2 |
| 1/20/21 2:00 PM | CD Alcoyano | Real Madrid | 2-1a.e.t |
| 1/21/21 12:00 PM | UD Ibiza Eivissa | Athletic Bilbao | 1-2 |
| 1/21/21 2:00 PM | UE Cornella | FC Barcelona | 0-2a.e.t |