| Date | Home | Away | Result |
|---|---|---|---|
| 1/4/22 2:00 PM | SD Ponferradina | Espanyol Barcelona | 2-4a.PSO |
| 1/5/22 9:00 AM | SD Eibar | RCD Mallorca | 1-2 |
| 1/5/22 9:00 AM | FC Cartagena | FC Valencia | 1-2 |
| 1/5/22 9:00 AM | CD Leganes | Real Sociedad | 2-3 |
| 1/5/22 12:30 PM | Linares Deportivo | FC Barcelona | 1-2 |
| 1/5/22 1:00 PM | CD Mirandes | Rayo Vallecano | 0-1 |
| 1/5/22 1:00 PM | Atletico Baleares | Celta Vigo | 2-1 |
| 1/5/22 1:00 PM | Real Valladolid | Real Betis Sevilla | 0-3 |
| 1/5/22 2:30 PM | CD Alcoyano | Real Madrid | 1-3 |
| 1/6/22 9:00 AM | FC Girona | CA Osasuna | 1-0 |
| 1/6/22 9:00 AM | CF Fuenlabrada | FC Cadiz | 0-1 |
| 1/6/22 11:00 AM | Sporting Gijon | FC Villarreal | 2-1 |
| 1/6/22 11:00 AM | Real Saragossa | FC Sevilla | 0-2 |
| 1/6/22 1:00 PM | UD Almeria | FC Elche | 1-2 |
| 1/6/22 1:00 PM | Atletico Mancha Real | Athletic Bilbao | 0-2 |
| 1/6/22 2:30 PM | CF Rayo Majadahonda | Atletico Madrid | 0-5 |