| Date | Home | Away | Result |
|---|---|---|---|
| 1/26/21 12:00 PM | Real Valladolid | UD Levante | 2-4 |
| 1/26/21 2:00 PM | Real Betis Sevilla | Real Sociedad | 3-1a.e.t |
| 1/26/21 2:00 PM | FC Girona | FC Villarreal | 0-1 |
| 1/27/21 12:00 PM | FC Sevilla | FC Valencia | 3-0 |
| 1/27/21 2:00 PM | UD Almeria | CA Osasuna | 5-4a.PSO |
| 1/27/21 2:00 PM | Rayo Vallecano | FC Barcelona | 1-2 |
| 1/28/21 12:00 PM | CD Artistico Navalcarnero | FC Granada | 0-6 |
| 1/28/21 2:00 PM | CD Alcoyano | Athletic Bilbao | 1-2 |