| Date | Home | Away | Result |
|---|---|---|---|
| 1/15/22 9:00 AM | RCD Mallorca | Espanyol Barcelona | 2-1 |
| 1/15/22 11:30 AM | FC Girona | Rayo Vallecano | 1-2 |
| 1/15/22 11:30 AM | Sporting Gijon | FC Cadiz | 2-4a.PSO |
| 1/16/22 5:00 AM | Atletico Baleares | FC Valencia | 0-1 |
| 1/16/22 9:00 AM | Real Betis Sevilla | FC Sevilla | 2-1 |
| 1/19/22 2:00 PM | Real Sociedad | Atletico Madrid | 2-0 |
| 1/20/22 12:00 PM | FC Elche | Real Madrid | 1-2a.e.t |
| 1/20/22 2:30 PM | Athletic Bilbao | FC Barcelona | 3-2a.e.t |