| Date | Home | Away | Result |
|---|---|---|---|
| 2/20/25 5:45 PM | FK Bodö/Glimt | FC Twente Enschede | 5-2a.e.t |
| 2/20/25 5:45 PM | FCSB Bukarest | PAOK Saloniki | 2-0 |
| 2/20/25 5:45 PM | Galatasaray Istanbul | AZ Alkmaar | 2-2 |
| 2/20/25 5:45 PM | AS Roma | FC Porto | 3-2 |
| 2/20/25 8:00 PM | RSC Anderlecht | Fenerbahce Istanbul | 2-2 |
| 2/20/25 8:00 PM | Ajax Amsterdam | Royale Union Saint-Gilloise | 1-2a.e.t |
| 2/20/25 8:00 PM | Real Sociedad | FC Midtjylland | 5-2 |
| 2/20/25 8:00 PM | Viktoria Plzen | Ferencvaros Budapest | 3-0 |