| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 10/5/23 11:45 AM | TSC Backa Topola | Olympiakos Piräus | Group A | 2-2 |
| 10/5/23 11:45 AM | SC Freiburg | West Ham United | Group A | 1-2 |
| 10/5/23 11:45 AM | Olympique Marseille | Brighton and Hove Albion | Group B | 2-2 |
| 10/5/23 11:45 AM | AEK Athens | Ajax Amsterdam | Group B | 1-1 |
| 10/5/23 11:45 AM | Real Betis Sevilla | Sparta Prag | Group C | 2-1 |
| 10/5/23 11:45 AM | Aris Limassol | Glasgow Rangers | Group C | 2-1 |
| 10/5/23 11:45 AM | KS Rakow Czestochowa | SK Sturm Graz | Group D | 0-1 |
| 10/5/23 11:45 AM | Sporting Lisbon | Atalanta Bergamo | Group D | 1-2 |
| 10/5/23 2:00 PM | Molde FK | Bayer 04 Leverkusen | Group H | 1-2 |
| 10/5/23 2:00 PM | BK Häcken | Qarabag | Group H | 0-1 |
| 10/5/23 2:00 PM | AS Roma | Servette FC Genève | Group G | 4-0 |
| 10/5/23 2:00 PM | Slavia Prag | Sheriff Tiraspol | Group G | 6-0 |
| 10/5/23 2:00 PM | Liverpool FC | Royale Union Saint-Gilloise | Group E | 2-0 |
| 10/5/23 2:00 PM | FC Toulouse | Linzer ASK | Group E | 1-0 |
| 10/5/23 2:00 PM | FC Villarreal | Stade Rennes | Group F | 1-0 |
| 10/5/23 2:00 PM | Maccabi Haifa | Panathinaikos Athens | Group F | 0-0 |