| Date | Home | Away | Result |
|---|---|---|---|
| 10/23/24 9:30 AM | Sporting Braga | FK Bodö/Glimt | 1-2 |
| 10/23/24 9:30 AM | Galatasaray Istanbul | IF Elfsborg Boras | 4-3 |
| 10/24/24 11:45 AM | AS Roma | Dynamo Kiew | 1-0 |
| 10/24/24 11:45 AM | Eintracht Frankfurt | Rigas Futbola Skola | 1-0 |
| 10/24/24 11:45 AM | Maccabi Tel Aviv | Real Sociedad | 1-2 |
| 10/24/24 11:45 AM | Ferencvaros Budapest | OGC Nice | 1-0 |
| 10/24/24 11:45 AM | PAOK Saloniki | Viktoria Plzen | 2-2 |
| 10/24/24 11:45 AM | FC Midtjylland | Royale Union Saint-Gilloise | 1-0 |
| 10/24/24 11:45 AM | Qarabag | Ajax Amsterdam | 0-3 |
| 10/24/24 2:00 PM | Fenerbahce Istanbul | Manchester United | 1-1 |
| 10/24/24 2:00 PM | Glasgow Rangers | FCSB Bukarest | 4-0 |
| 10/24/24 2:00 PM | FC Porto | 1899 Hoffenheim | 2-0 |
| 10/24/24 2:00 PM | Tottenham Hotspur | AZ Alkmaar | 1-0 |
| 10/24/24 2:00 PM | Olympique Lyon | Besiktas Istanbul | 0-1 |
| 10/24/24 2:00 PM | Malmö FF | Olympiakos Piräus | 0-1 |
| 10/24/24 2:00 PM | FC Twente Enschede | Lazio Rom | 0-2 |
| 10/24/24 2:00 PM | RSC Anderlecht | PFC Ludogorets Razgrad | 2-0 |
| 10/24/24 2:00 PM | Athletic Bilbao | Slavia Prag | 1-0 |