| Date | Home | Away | Result |
|---|---|---|---|
| 11/28/24 5:45 PM | Lazio Rom | PFC Ludogorets Razgrad | 0-0 |
| 11/28/24 5:45 PM | Dynamo Kiew | Viktoria Plzen | 1-2 |
| 11/28/24 5:45 PM | Qarabag | Olympique Lyon | 1-4 |
| 11/28/24 5:45 PM | Besiktas Istanbul | Maccabi Tel Aviv | 1-3 |
| 11/28/24 5:45 PM | Rigas Futbola Skola | PAOK Saloniki | 0-2 |
| 11/28/24 5:45 PM | RSC Anderlecht | FC Porto | 2-2 |
| 11/28/24 5:45 PM | Athletic Bilbao | IF Elfsborg Boras | 3-0 |
| 11/28/24 5:45 PM | AZ Alkmaar | Galatasaray Istanbul | 1-1 |
| 11/28/24 8:00 PM | Slavia Prag | Fenerbahce Istanbul | 1-2 |
| 11/28/24 8:00 PM | Manchester United | FK Bodö/Glimt | 3-2 |
| 11/28/24 8:00 PM | Tottenham Hotspur | AS Roma | 2-2 |
| 11/28/24 8:00 PM | Ferencvaros Budapest | Malmö FF | 4-1 |
| 11/28/24 8:00 PM | Sporting Braga | 1899 Hoffenheim | 3-0 |
| 11/28/24 8:00 PM | Real Sociedad | Ajax Amsterdam | 2-0 |
| 11/28/24 8:00 PM | FC Midtjylland | Eintracht Frankfurt | 1-2 |
| 11/28/24 8:00 PM | FCSB Bukarest | Olympiakos Piräus | 0-0 |
| 11/28/24 8:00 PM | OGC Nice | Glasgow Rangers | 1-4 |
| 11/28/24 8:00 PM | FC Twente Enschede | Royale Union Saint-Gilloise | 0-1 |