| Date | Home | Away | Result |
|---|---|---|---|
| 1/21/25 9:30 AM | Galatasaray Istanbul | Dynamo Kiew | --- |
| 1/22/25 9:30 AM | Besiktas Istanbul | Athletic Bilbao | --- |
| 1/23/25 11:45 AM | AZ Alkmaar | AS Roma | --- |
| 1/23/25 11:45 AM | Malmö FF | FC Twente Enschede | --- |
| 1/23/25 11:45 AM | FK Bodö/Glimt | Maccabi Tel Aviv | --- |
| 1/23/25 11:45 AM | Qarabag | FCSB Bukarest | --- |
| 1/23/25 11:45 AM | Viktoria Plzen | RSC Anderlecht | --- |
| 1/23/25 11:45 AM | 1899 Hoffenheim | Tottenham Hotspur | --- |
| 1/23/25 11:45 AM | FC Porto | Olympiakos Piräus | --- |
| 1/23/25 11:45 AM | Fenerbahce Istanbul | Olympique Lyon | --- |
| 1/23/25 2:00 PM | Rigas Futbola Skola | Ajax Amsterdam | --- |
| 1/23/25 2:00 PM | PFC Ludogorets Razgrad | FC Midtjylland | --- |
| 1/23/25 2:00 PM | Royale Union Saint-Gilloise | Sporting Braga | --- |
| 1/23/25 2:00 PM | IF Elfsborg Boras | OGC Nice | --- |
| 1/23/25 2:00 PM | Eintracht Frankfurt | Ferencvaros Budapest | --- |
| 1/23/25 2:00 PM | Manchester United | Glasgow Rangers | --- |
| 1/23/25 2:00 PM | Lazio Rom | Real Sociedad | --- |
| 1/23/25 2:00 PM | PAOK Saloniki | Slavia Prag | --- |