| Date | Home | Away | Result |
|---|---|---|---|
| 1/30/25 8:00 PM | FCSB Bukarest | Manchester United | 0-2 |
| 1/30/25 8:00 PM | RSC Anderlecht | 1899 Hoffenheim | 3-4 |
| 1/30/25 8:00 PM | Athletic Bilbao | Viktoria Plzen | 3-1 |
| 1/30/25 8:00 PM | OGC Nice | FK Bodö/Glimt | 1-1 |
| 1/30/25 8:00 PM | Olympique Lyon | PFC Ludogorets Razgrad | 1-1 |
| 1/30/25 8:00 PM | FC Midtjylland | Fenerbahce Istanbul | 2-2 |
| 1/30/25 8:00 PM | Dynamo Kiew | Rigas Futbola Skola | 1-0 |
| 1/30/25 8:00 PM | FC Twente Enschede | Besiktas Istanbul | 1-0 |
| 1/30/25 8:00 PM | AS Roma | Eintracht Frankfurt | 2-0 |
| 1/30/25 8:00 PM | Glasgow Rangers | Royale Union Saint-Gilloise | 2-1 |
| 1/30/25 8:00 PM | Slavia Prag | Malmö FF | 2-2 |
| 1/30/25 8:00 PM | Tottenham Hotspur | IF Elfsborg Boras | 3-0 |
| 1/30/25 8:00 PM | Maccabi Tel Aviv | FC Porto | 0-1 |
| 1/30/25 8:00 PM | Ajax Amsterdam | Galatasaray Istanbul | 2-1 |
| 1/30/25 8:00 PM | Ferencvaros Budapest | AZ Alkmaar | 4-3 |
| 1/30/25 8:00 PM | Sporting Braga | Lazio Rom | 1-0 |
| 1/30/25 8:00 PM | Olympiakos Piräus | Qarabag | 3-0 |
| 1/30/25 8:00 PM | Real Sociedad | PAOK Saloniki | 2-0 |