Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| NFL | 9/10/21 12:20 AM | 9/10/21 12:18 AM | Tampa Bay Buccaneers | Dallas Cowboys | 31-29 | 5 - 25 points |
| NFL | 9/12/21 5:00 PM | 9/12/21 4:58 PM | Houston Texans | Jacksonville Jaguars | 37-21 | 5 - 25 points |
| NFL | 9/12/21 5:00 PM | 9/12/21 4:58 PM | Detroit Lions | San Francisco 49ers | 33-41 | 5 - 25 points |
| NFL | 9/12/21 5:00 PM | 9/12/21 4:58 PM | Cincinnati Bengals | Minnesota Vikings | 27-24OT | 5 - 25 points |
| NFL | 9/12/21 5:00 PM | 9/12/21 4:58 PM | Carolina Panthers | New York Jets | 19-14 | 5 - 25 points |
| NFL | 9/12/21 5:00 PM | 9/12/21 4:58 PM | Buffalo Bills | Pittsburgh Steelers | 16-23 | 5 - 25 points |
| NFL | 9/12/21 5:00 PM | 9/12/21 4:58 PM | Atlanta Falcons | Philadelphia Eagles | 6-32 | 5 - 25 points |
| NFL | 9/12/21 5:00 PM | 9/12/21 4:58 PM | Washington Football Team | Los Angeles Chargers | 16-20 | 5 - 25 points |
| NFL | 9/12/21 5:00 PM | 9/12/21 4:58 PM | Tennessee Titans | Arizona Cardinals | 13-38 | 5 - 25 points |
| NFL | 9/12/21 5:00 PM | 9/12/21 4:58 PM | Indianapolis Colts | Seattle Seahawks | 16-28 | 5 - 25 points |
| NFL | 9/12/21 8:25 PM | 9/12/21 8:23 PM | New York Giants | Denver Broncos | 13-27 | 5 - 25 points |
| NFL | 9/12/21 8:25 PM | 9/12/21 8:23 PM | New Orleans Saints | Green Bay Packers | 38-3 | 5 - 25 points |
| NFL | 9/12/21 8:25 PM | 9/12/21 8:23 PM | New England Patriots | Miami Dolphins | 16-17 | 5 - 25 points |
| NFL | 9/12/21 8:25 PM | 9/12/21 8:23 PM | Kansas City Chiefs | Cleveland Browns | 33-29 | 5 - 25 points |
| NFL | 9/13/21 12:20 AM | 9/13/21 12:18 AM | Los Angeles Rams | Chicago Bears | 34-14 | 5 - 25 points |
| NFL | 9/14/21 12:15 AM | 9/14/21 12:13 AM | Las Vegas Raiders | Baltimore Ravens | 33-27OT | 5 - 25 points |