Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| NFL | 11/25/21 5:30 PM | 11/25/21 5:28 PM | Detroit Lions | Chicago Bears | 14-16 | 5 - 25 points |
| NFL | 11/25/21 9:30 PM | 11/25/21 9:28 PM | Dallas Cowboys | Las Vegas Raiders | 33-36OT | 5 - 25 points |
| NFL | 11/26/21 1:20 AM | 11/26/21 1:18 AM | New Orleans Saints | Buffalo Bills | 6-31 | 5 - 25 points |
| NFL | 11/28/21 6:00 PM | 11/28/21 5:58 PM | Jacksonville Jaguars | Atlanta Falcons | 14-21 | 5 - 25 points |
| NFL | 11/28/21 6:00 PM | 11/28/21 5:58 PM | Cincinnati Bengals | Pittsburgh Steelers | 41-10 | 5 - 25 points |
| NFL | 11/28/21 6:00 PM | 11/28/21 5:58 PM | New England Patriots | Tennessee Titans | 36-13 | 5 - 25 points |
| NFL | 11/28/21 6:00 PM | 11/28/21 5:58 PM | Miami Dolphins | Carolina Panthers | 33-10 | 5 - 25 points |
| NFL | 11/28/21 6:00 PM | 11/28/21 5:58 PM | New York Giants | Philadelphia Eagles | 13-7 | 5 - 25 points |
| NFL | 11/28/21 6:00 PM | 11/28/21 5:58 PM | Houston Texans | New York Jets | 14-21 | 5 - 25 points |
| NFL | 11/28/21 6:00 PM | 11/28/21 5:58 PM | Indianapolis Colts | Tampa Bay Buccaneers | 31-38 | 5 - 25 points |
| NFL | 11/28/21 9:05 PM | 11/28/21 9:03 PM | Denver Broncos | Los Angeles Chargers | 28-13 | 5 - 25 points |
| NFL | 11/28/21 9:25 PM | 11/28/21 9:23 PM | San Francisco 49ers | Minnesota Vikings | 34-26 | 5 - 25 points |
| NFL | 11/28/21 9:25 PM | 11/28/21 9:23 PM | Green Bay Packers | Los Angeles Rams | 36-28 | 5 - 25 points |
| NFL | 11/29/21 1:20 AM | 11/29/21 1:18 AM | Baltimore Ravens | Cleveland Browns | 16-10 | 5 - 25 points |
| NFL | 11/30/21 1:15 AM | 11/30/21 1:13 AM | Washington Football Team | Seattle Seahawks | 17-15 | 5 - 25 points |