Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| NFL | 9/24/21 12:20 AM | 9/24/21 12:18 AM | Houston Texans | Carolina Panthers | 9-24 | 5 - 25 points |
| NFL | 9/26/21 5:00 PM | 9/26/21 4:58 PM | Jacksonville Jaguars | Arizona Cardinals | 19-31 | 5 - 25 points |
| NFL | 9/26/21 5:00 PM | 9/26/21 4:58 PM | New England Patriots | New Orleans Saints | 13-28 | 5 - 25 points |
| NFL | 9/26/21 5:00 PM | 9/26/21 4:58 PM | Detroit Lions | Baltimore Ravens | 17-19 | 5 - 25 points |
| NFL | 9/26/21 5:00 PM | 9/26/21 4:58 PM | Cleveland Browns | Chicago Bears | 26-6 | 5 - 25 points |
| NFL | 9/26/21 5:00 PM | 9/26/21 4:58 PM | Pittsburgh Steelers | Cincinnati Bengals | 10-24 | 5 - 25 points |
| NFL | 9/26/21 5:00 PM | 9/26/21 4:58 PM | Kansas City Chiefs | Los Angeles Chargers | 24-30 | 5 - 25 points |
| NFL | 9/26/21 5:00 PM | 9/26/21 4:58 PM | New York Giants | Atlanta Falcons | 14-17 | 5 - 25 points |
| NFL | 9/26/21 5:00 PM | 9/26/21 4:58 PM | Tennessee Titans | Indianapolis Colts | 25-16 | 5 - 25 points |
| NFL | 9/26/21 5:00 PM | 9/26/21 4:58 PM | Buffalo Bills | Washington Football Team | 43-21 | 5 - 25 points |
| NFL | 9/26/21 8:05 PM | 9/26/21 8:03 PM | Las Vegas Raiders | Miami Dolphins | 31-28OT | 5 - 25 points |
| NFL | 9/26/21 8:05 PM | 9/26/21 8:03 PM | Denver Broncos | New York Jets | 26-0 | 5 - 25 points |
| NFL | 9/26/21 8:25 PM | 9/26/21 8:23 PM | Los Angeles Rams | Tampa Bay Buccaneers | 34-24 | 5 - 25 points |
| NFL | 9/26/21 8:25 PM | 9/26/21 8:23 PM | Minnesota Vikings | Seattle Seahawks | 30-17 | 5 - 25 points |
| NFL | 9/27/21 12:20 AM | 9/27/21 12:18 AM | San Francisco 49ers | Green Bay Packers | 28-30 | 5 - 25 points |
| NFL | 9/28/21 12:15 AM | 9/28/21 12:13 AM | Dallas Cowboys | Philadelphia Eagles | 41-21 | 5 - 25 points |