Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| NFL | 10/7/21 7:20 PM | 10/7/21 7:18 PM | Seattle Seahawks | Los Angeles Rams | 17-26 | 5 - 25 points |
| NFL | 10/10/21 8:30 AM | 10/10/21 8:28 AM | Atlanta Falcons | New York Jets | 27-20 | 5 - 25 points |
| NFL | 10/10/21 12:00 PM | 10/10/21 11:58 AM | Jacksonville Jaguars | Tennessee Titans | 19-37 | 5 - 25 points |
| NFL | 10/10/21 12:00 PM | 10/10/21 11:58 AM | Carolina Panthers | Philadelphia Eagles | 18-21 | 5 - 25 points |
| NFL | 10/10/21 12:00 PM | 10/10/21 11:58 AM | Pittsburgh Steelers | Denver Broncos | 27-19 | 5 - 25 points |
| NFL | 10/10/21 12:00 PM | 10/10/21 11:58 AM | Cincinnati Bengals | Green Bay Packers | 22-25OT | 5 - 25 points |
| NFL | 10/10/21 12:00 PM | 10/10/21 11:58 AM | Tampa Bay Buccaneers | Miami Dolphins | 45-17 | 5 - 25 points |
| NFL | 10/10/21 12:00 PM | 10/10/21 11:58 AM | Houston Texans | New England Patriots | 22-25 | 5 - 25 points |
| NFL | 10/10/21 12:00 PM | 10/10/21 11:58 AM | Washington Football Team | New Orleans Saints | 22-33 | 5 - 25 points |
| NFL | 10/10/21 12:00 PM | 10/10/21 11:58 AM | Minnesota Vikings | Detroit Lions | 19-17 | 5 - 25 points |
| NFL | 10/10/21 3:05 PM | 10/10/21 3:03 PM | Los Angeles Chargers | Cleveland Browns | 47-42 | 5 - 25 points |
| NFL | 10/10/21 3:05 PM | 10/10/21 3:03 PM | Las Vegas Raiders | Chicago Bears | 9-20 | 5 - 25 points |
| NFL | 10/10/21 3:25 PM | 10/10/21 3:23 PM | Dallas Cowboys | New York Giants | 44-20 | 5 - 25 points |
| NFL | 10/10/21 3:25 PM | 10/10/21 3:23 PM | Arizona Cardinals | San Francisco 49ers | 17-10 | 5 - 25 points |
| NFL | 10/10/21 7:20 PM | 10/10/21 7:18 PM | Kansas City Chiefs | Buffalo Bills | 20-38 | 5 - 25 points |
| NFL | 10/11/21 7:15 PM | 10/11/21 7:13 PM | Baltimore Ravens | Indianapolis Colts | 31-25OT | 5 - 25 points |