Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| NFL | 10/8/21 12:20 AM | 10/8/21 12:18 AM | Seattle Seahawks | Los Angeles Rams | 17-26 | 5 - 25 points |
| NFL | 10/10/21 1:30 PM | 10/10/21 1:28 PM | Atlanta Falcons | New York Jets | 27-20 | 5 - 25 points |
| NFL | 10/10/21 5:00 PM | 10/10/21 4:58 PM | Jacksonville Jaguars | Tennessee Titans | 19-37 | 5 - 25 points |
| NFL | 10/10/21 5:00 PM | 10/10/21 4:58 PM | Carolina Panthers | Philadelphia Eagles | 18-21 | 5 - 25 points |
| NFL | 10/10/21 5:00 PM | 10/10/21 4:58 PM | Pittsburgh Steelers | Denver Broncos | 27-19 | 5 - 25 points |
| NFL | 10/10/21 5:00 PM | 10/10/21 4:58 PM | Cincinnati Bengals | Green Bay Packers | 22-25OT | 5 - 25 points |
| NFL | 10/10/21 5:00 PM | 10/10/21 4:58 PM | Tampa Bay Buccaneers | Miami Dolphins | 45-17 | 5 - 25 points |
| NFL | 10/10/21 5:00 PM | 10/10/21 4:58 PM | Houston Texans | New England Patriots | 22-25 | 5 - 25 points |
| NFL | 10/10/21 5:00 PM | 10/10/21 4:58 PM | Washington Football Team | New Orleans Saints | 22-33 | 5 - 25 points |
| NFL | 10/10/21 5:00 PM | 10/10/21 4:58 PM | Minnesota Vikings | Detroit Lions | 19-17 | 5 - 25 points |
| NFL | 10/10/21 8:05 PM | 10/10/21 8:03 PM | Los Angeles Chargers | Cleveland Browns | 47-42 | 5 - 25 points |
| NFL | 10/10/21 8:05 PM | 10/10/21 8:03 PM | Las Vegas Raiders | Chicago Bears | 9-20 | 5 - 25 points |
| NFL | 10/10/21 8:25 PM | 10/10/21 8:23 PM | Dallas Cowboys | New York Giants | 44-20 | 5 - 25 points |
| NFL | 10/10/21 8:25 PM | 10/10/21 8:23 PM | Arizona Cardinals | San Francisco 49ers | 17-10 | 5 - 25 points |
| NFL | 10/11/21 12:20 AM | 10/11/21 12:18 AM | Kansas City Chiefs | Buffalo Bills | 20-38 | 5 - 25 points |
| NFL | 10/12/21 12:15 AM | 10/12/21 12:13 AM | Baltimore Ravens | Indianapolis Colts | 31-25OT | 5 - 25 points |