Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| NFL | 10/15/21 12:20 AM | 10/15/21 12:18 AM | Philadelphia Eagles | Tampa Bay Buccaneers | 22-28 | 5 - 25 points |
| NFL | 10/17/21 1:30 PM | 10/17/21 1:28 PM | Jacksonville Jaguars | Miami Dolphins | 23-20 | 5 - 25 points |
| NFL | 10/17/21 5:00 PM | 10/17/21 4:58 PM | Carolina Panthers | Minnesota Vikings | 28-34OT | 5 - 25 points |
| NFL | 10/17/21 5:00 PM | 10/17/21 4:58 PM | Baltimore Ravens | Los Angeles Chargers | 34-6 | 5 - 25 points |
| NFL | 10/17/21 5:00 PM | 10/17/21 4:58 PM | Chicago Bears | Green Bay Packers | 14-24 | 5 - 25 points |
| NFL | 10/17/21 5:00 PM | 10/17/21 4:58 PM | Detroit Lions | Cincinnati Bengals | 11-34 | 5 - 25 points |
| NFL | 10/17/21 5:00 PM | 10/17/21 4:58 PM | Indianapolis Colts | Houston Texans | 31-3 | 5 - 25 points |
| NFL | 10/17/21 5:00 PM | 10/17/21 4:58 PM | New York Giants | Los Angeles Rams | 11-38 | 5 - 25 points |
| NFL | 10/17/21 5:00 PM | 10/17/21 4:58 PM | Washington Football Team | Kansas City Chiefs | 13-31 | 5 - 25 points |
| NFL | 10/17/21 8:05 PM | 10/17/21 8:03 PM | Cleveland Browns | Arizona Cardinals | 14-37 | 5 - 25 points |
| NFL | 10/17/21 8:25 PM | 10/17/21 8:23 PM | New England Patriots | Dallas Cowboys | 29-35OT | 5 - 25 points |
| NFL | 10/17/21 8:25 PM | 10/17/21 8:23 PM | Denver Broncos | Las Vegas Raiders | 24-34 | 5 - 25 points |
| NFL | 10/18/21 12:20 AM | 10/18/21 12:18 AM | Pittsburgh Steelers | Seattle Seahawks | 23-20OT | 5 - 25 points |
| NFL | 10/19/21 12:15 AM | 10/19/21 12:13 AM | Tennessee Titans | Buffalo Bills | 34-31 | 5 - 25 points |