Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| NFL | 10/22/21 12:20 AM | 10/22/21 12:18 AM | Cleveland Browns | Denver Broncos | 17-14 | 5 - 25 points |
| NFL | 10/24/21 5:00 PM | 10/24/21 4:58 PM | Baltimore Ravens | Cincinnati Bengals | 17-41 | 5 - 25 points |
| NFL | 10/24/21 5:00 PM | 10/24/21 4:58 PM | Miami Dolphins | Atlanta Falcons | 28-30 | 5 - 25 points |
| NFL | 10/24/21 5:00 PM | 10/24/21 4:58 PM | Green Bay Packers | Washington Football Team | 24-10 | 5 - 25 points |
| NFL | 10/24/21 5:00 PM | 10/24/21 4:58 PM | Tennessee Titans | Kansas City Chiefs | 27-3 | 5 - 25 points |
| NFL | 10/24/21 5:00 PM | 10/24/21 4:58 PM | New England Patriots | New York Jets | 54-13 | 5 - 25 points |
| NFL | 10/24/21 5:00 PM | 10/24/21 4:58 PM | New York Giants | Carolina Panthers | 25-3 | 5 - 25 points |
| NFL | 10/24/21 8:05 PM | 10/24/21 8:03 PM | Las Vegas Raiders | Philadelphia Eagles | 33-22 | 5 - 25 points |
| NFL | 10/24/21 8:05 PM | 10/24/21 8:03 PM | Los Angeles Rams | Detroit Lions | 28-19 | 5 - 25 points |
| NFL | 10/24/21 8:25 PM | 10/24/21 8:23 PM | Tampa Bay Buccaneers | Chicago Bears | 38-3 | 5 - 25 points |
| NFL | 10/24/21 8:25 PM | 10/24/21 8:23 PM | Arizona Cardinals | Houston Texans | 31-5 | 5 - 25 points |
| NFL | 10/25/21 12:20 AM | 10/25/21 12:18 AM | San Francisco 49ers | Indianapolis Colts | 18-30 | 5 - 25 points |
| NFL | 10/26/21 12:15 AM | 10/26/21 12:13 AM | Seattle Seahawks | New Orleans Saints | 10-13 | 5 - 25 points |