Schedule
| Competition | Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|---|
| NFL | 11/5/21 12:20 AM | 11/5/21 12:18 AM | Indianapolis Colts | New York Jets | 45-30 | 5 - 25 points |
| NFL | 11/7/21 6:00 PM | 11/7/21 5:58 PM | New York Giants | Las Vegas Raiders | 23-16 | 5 - 25 points |
| NFL | 11/7/21 6:00 PM | 11/7/21 5:58 PM | Miami Dolphins | Houston Texans | 17-9 | 5 - 25 points |
| NFL | 11/7/21 6:00 PM | 11/7/21 5:58 PM | Jacksonville Jaguars | Buffalo Bills | 9-6 | 5 - 25 points |
| NFL | 11/7/21 6:00 PM | 11/7/21 5:58 PM | Cincinnati Bengals | Cleveland Browns | 16-41 | 5 - 25 points |
| NFL | 11/7/21 6:00 PM | 11/7/21 5:58 PM | Baltimore Ravens | Minnesota Vikings | 34-31OT | 5 - 25 points |
| NFL | 11/7/21 6:00 PM | 11/7/21 5:58 PM | Carolina Panthers | New England Patriots | 6-24 | 5 - 25 points |
| NFL | 11/7/21 6:00 PM | 11/7/21 5:58 PM | Dallas Cowboys | Denver Broncos | 16-30 | 5 - 25 points |
| NFL | 11/7/21 6:00 PM | 11/7/21 5:58 PM | New Orleans Saints | Atlanta Falcons | 25-27 | 5 - 25 points |
| NFL | 11/7/21 9:05 PM | 11/7/21 9:03 PM | Philadelphia Eagles | Los Angeles Chargers | 24-27 | 5 - 25 points |
| NFL | 11/7/21 9:25 PM | 11/7/21 9:23 PM | San Francisco 49ers | Arizona Cardinals | 17-31 | 5 - 25 points |
| NFL | 11/7/21 9:25 PM | 11/7/21 9:23 PM | Kansas City Chiefs | Green Bay Packers | 13-7 | 5 - 25 points |
| NFL | 11/8/21 1:20 AM | 11/8/21 1:18 AM | Los Angeles Rams | Tennessee Titans | 16-28 | 5 - 25 points |
| NFL | 11/9/21 1:15 AM | 11/9/21 1:13 AM | Pittsburgh Steelers | Chicago Bears | 29-27 | 5 - 25 points |