Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/8/22 7:20 PM | 9/8/22 7:20 PM | Los Angeles Rams | Buffalo Bills | 10-31 | 4 - 10 - 4 |
| 9/11/22 12:00 PM | 9/11/22 12:00 PM | Miami Dolphins | New England Patriots | 20-7 | 4 - 10 - 5 |
| 9/11/22 12:00 PM | 9/11/22 12:00 PM | Houston Texans | Indianapolis Colts | 20-20OT | 8 - 10 - 3 |
| 9/11/22 12:00 PM | 9/11/22 12:00 PM | New York Jets | Baltimore Ravens | 9-24 | 10 - 10 - 3 |
| 9/11/22 12:00 PM | 9/11/22 12:00 PM | Detroit Lions | Philadelphia Eagles | 35-38 | 6 - 10 - 3 |
| 9/11/22 12:00 PM | 9/11/22 12:00 PM | Cincinnati Bengals | Pittsburgh Steelers | 20-23OT | 3 - 10 - 7 |
| 9/11/22 12:00 PM | 9/11/22 12:00 PM | Carolina Panthers | Cleveland Browns | 24-26 | 4 - 10 - 5 |
| 9/11/22 12:00 PM | 9/11/22 12:00 PM | Chicago Bears | San Francisco 49ers | 19-10 | 10 - 10 - 3 |
| 9/11/22 12:00 PM | 9/11/22 12:00 PM | Washington Commanders | Jacksonville Jaguars | 28-22 | 4 - 10 - 4 |
| 9/11/22 12:00 PM | 9/11/22 12:00 PM | Atlanta Falcons | New Orleans Saints | 26-27 | 6 - 10 - 3 |
| 9/11/22 3:25 PM | 9/11/22 3:25 PM | Minnesota Vikings | Green Bay Packers | 23-7 | 6 - 10 - 3 |
| 9/11/22 3:25 PM | 9/11/22 3:25 PM | Arizona Cardinals | Kansas City Chiefs | 21-44 | 7 - 10 - 3 |
| 9/11/22 3:25 PM | 9/11/22 3:25 PM | Tennessee Titans | New York Giants | 20-21 | 3 - 10 - 8 |
| 9/11/22 3:25 PM | 9/11/22 3:25 PM | Los Angeles Chargers | Las Vegas Raiders | 24-19 | 3 - 10 - 5 |
| 9/11/22 7:20 PM | 9/11/22 7:20 PM | Dallas Cowboys | Tampa Bay Buccaneers | 3-19 | 5 - 10 - 4 |
| 9/12/22 7:15 PM | 9/12/22 7:15 PM | Seattle Seahawks | Denver Broncos | 17-16 | 7 - 10 - 3 |