Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/11/21 7:20 PM | 11/11/21 7:20 PM | Miami Dolphins | Baltimore Ravens | 22-10 | 10 - 10 - 3 |
| 11/14/21 12:00 PM | 11/14/21 12:00 PM | New England Patriots | Cleveland Browns | 45-7 | 4 - 10 - 4 |
| 11/14/21 12:00 PM | 11/14/21 12:00 PM | Pittsburgh Steelers | Detroit Lions | 16-16OT | 3 - 10 - 10 |
| 11/14/21 12:00 PM | 11/14/21 12:00 PM | Indianapolis Colts | Jacksonville Jaguars | 23-17 | 3 - 10 - 10 |
| 11/14/21 12:00 PM | 11/14/21 12:00 PM | Tennessee Titans | New Orleans Saints | 23-21 | 4 - 10 - 5 |
| 11/14/21 12:00 PM | 11/14/21 12:00 PM | Dallas Cowboys | Atlanta Falcons | 43-3 | 3 - 10 - 10 |
| 11/14/21 12:00 PM | 11/14/21 12:00 PM | Washington Football Team | Tampa Bay Buccaneers | 29-19 | 10 - 10 - 3 |
| 11/14/21 12:00 PM | 11/14/21 12:00 PM | New York Jets | Buffalo Bills | 17-45 | 10 - 10 - 3 |
| 11/14/21 3:05 PM | 11/14/21 3:05 PM | Arizona Cardinals | Carolina Panthers | 10-34 | 3 - 10 - 10 |
| 11/14/21 3:05 PM | 11/14/21 3:05 PM | Los Angeles Chargers | Minnesota Vikings | 20-27 | 3 - 10 - 6 |
| 11/14/21 3:25 PM | 11/14/21 3:25 PM | Green Bay Packers | Seattle Seahawks | 17-0 | 3 - 10 - 5 |
| 11/14/21 3:25 PM | 11/14/21 3:25 PM | Denver Broncos | Philadelphia Eagles | 13-30 | 3 - 10 - 5 |
| 11/14/21 7:20 PM | 11/14/21 7:20 PM | Las Vegas Raiders | Kansas City Chiefs | 14-41 | 5 - 10 - 4 |
| 11/15/21 7:15 PM | 11/15/21 7:15 PM | San Francisco 49ers | Los Angeles Rams | 31-10 | 10 - 10 - 3 |