Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/18/21 7:20 PM | 11/18/21 7:20 PM | Atlanta Falcons | New England Patriots | 0-25 | 10 - 10 - 3 |
| 11/21/21 12:00 PM | 11/21/21 12:00 PM | Chicago Bears | Baltimore Ravens | 13-16 | 7 - 10 - 3 |
| 11/21/21 12:00 PM | 11/21/21 12:00 PM | Minnesota Vikings | Green Bay Packers | 34-31 | 6 - 10 - 3 |
| 11/21/21 12:00 PM | 11/21/21 12:00 PM | Tennessee Titans | Houston Texans | 13-22 | 3 - 10 - 10 |
| 11/21/21 12:00 PM | 11/21/21 12:00 PM | Jacksonville Jaguars | San Francisco 49ers | 10-30 | 10 - 10 - 3 |
| 11/21/21 12:00 PM | 11/21/21 12:00 PM | Cleveland Browns | Detroit Lions | 13-10 | 3 - 10 - 10 |
| 11/21/21 12:00 PM | 11/21/21 12:00 PM | Buffalo Bills | Indianapolis Colts | 15-41 | 3 - 10 - 7 |
| 11/21/21 12:00 PM | 11/21/21 12:00 PM | Carolina Panthers | Washington Football Team | 21-27 | 3 - 10 - 6 |
| 11/21/21 12:00 PM | 11/21/21 12:00 PM | New York Jets | Miami Dolphins | 17-24 | 6 - 10 - 3 |
| 11/21/21 12:00 PM | 11/21/21 12:00 PM | Philadelphia Eagles | New Orleans Saints | 40-29 | 4 - 10 - 4 |
| 11/21/21 3:05 PM | 11/21/21 3:05 PM | Las Vegas Raiders | Cincinnati Bengals | 13-32 | 4 - 10 - 4 |
| 11/21/21 3:25 PM | 11/21/21 3:25 PM | Kansas City Chiefs | Dallas Cowboys | 19-9 | 4 - 10 - 4 |
| 11/21/21 3:25 PM | 11/21/21 3:25 PM | Seattle Seahawks | Arizona Cardinals | 13-23 | 5 - 10 - 4 |
| 11/21/21 7:20 PM | 11/21/21 7:20 PM | Los Angeles Chargers | Pittsburgh Steelers | 41-37 | 3 - 10 - 6 |
| 11/22/21 7:15 PM | 11/22/21 7:15 PM | Tampa Bay Buccaneers | New York Giants | 30-10 | 3 - 10 - 10 |