Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 1/2/22 12:00 PM | 1/2/22 12:00 PM | New York Jets | Tampa Bay Buccaneers | 24-28 | 10 - 10 - 3 |
| 1/2/22 12:00 PM | 1/2/22 12:00 PM | Washington Football Team | Philadelphia Eagles | 16-20 | 6 - 10 - 3 |
| 1/2/22 12:00 PM | 1/2/22 12:00 PM | Baltimore Ravens | Los Angeles Rams | 19-20 | 6 - 10 - 3 |
| 1/2/22 12:00 PM | 1/2/22 12:00 PM | Buffalo Bills | Atlanta Falcons | 29-15 | 3 - 10 - 10 |
| 1/2/22 12:00 PM | 1/2/22 12:00 PM | Chicago Bears | New York Giants | 29-3 | 3 - 10 - 8 |
| 1/2/22 12:00 PM | 1/2/22 12:00 PM | Cincinnati Bengals | Kansas City Chiefs | 34-31 | 6 - 10 - 3 |
| 1/2/22 12:00 PM | 1/2/22 12:00 PM | Indianapolis Colts | Las Vegas Raiders | 20-23 | 3 - 10 - 10 |
| 1/2/22 12:00 PM | 1/2/22 12:00 PM | New England Patriots | Jacksonville Jaguars | 50-10 | 3 - 10 - 10 |
| 1/2/22 12:00 PM | 1/2/22 12:00 PM | Tennessee Titans | Miami Dolphins | 34-3 | 4 - 10 - 5 |
| 1/2/22 3:05 PM | 1/2/22 3:05 PM | Los Angeles Chargers | Denver Broncos | 34-13 | 3 - 10 - 10 |
| 1/2/22 3:05 PM | 1/2/22 3:05 PM | San Francisco 49ers | Houston Texans | 23-7 | 3 - 10 - 10 |
| 1/2/22 3:25 PM | 1/2/22 3:25 PM | New Orleans Saints | Carolina Panthers | 18-10 | 3 - 10 - 8 |
| 1/2/22 3:25 PM | 1/2/22 3:25 PM | Seattle Seahawks | Detroit Lions | 51-29 | 3 - 10 - 7 |
| 1/2/22 3:25 PM | 1/2/22 3:25 PM | Dallas Cowboys | Arizona Cardinals | 22-25 | 3 - 10 - 6 |
| 1/2/22 7:20 PM | 1/2/22 7:20 PM | Green Bay Packers | Minnesota Vikings | 37-10 | 3 - 10 - 10 |
| 1/3/22 7:15 PM | 1/3/22 7:15 PM | Pittsburgh Steelers | Cleveland Browns | 26-14 | 4 - 10 - 4 |