Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/16/21 7:20 PM | 9/16/21 7:20 PM | Washington Football Team | New York Giants | 30-29 | 3 - 10 - 5 |
| 9/19/21 12:00 PM | 9/19/21 12:00 PM | Chicago Bears | Cincinnati Bengals | 20-17 | 4 - 10 - 4 |
| 9/19/21 12:00 PM | 9/19/21 12:00 PM | Pittsburgh Steelers | Las Vegas Raiders | 17-26 | 3 - 10 - 6 |
| 9/19/21 12:00 PM | 9/19/21 12:00 PM | Indianapolis Colts | Los Angeles Rams | 24-27 | 10 - 10 - 3 |
| 9/19/21 12:00 PM | 9/19/21 12:00 PM | Philadelphia Eagles | San Francisco 49ers | 11-17 | 6 - 10 - 3 |
| 9/19/21 12:00 PM | 9/19/21 12:00 PM | Miami Dolphins | Buffalo Bills | 0-35 | 8 - 10 - 3 |
| 9/19/21 12:00 PM | 9/19/21 12:00 PM | Jacksonville Jaguars | Denver Broncos | 13-23 | 5 - 10 - 3 |
| 9/19/21 12:00 PM | 9/19/21 12:00 PM | New York Jets | New England Patriots | 6-25 | 8 - 10 - 3 |
| 9/19/21 12:00 PM | 9/19/21 12:00 PM | Carolina Panthers | New Orleans Saints | 26-7 | 9 - 10 - 3 |
| 9/19/21 12:00 PM | 9/19/21 12:00 PM | Cleveland Browns | Houston Texans | 31-21 | 3 - 10 - 7 |
| 9/19/21 3:05 PM | 9/19/21 3:05 PM | Tampa Bay Buccaneers | Atlanta Falcons | 48-25 | 3 - 10 - 10 |
| 9/19/21 3:05 PM | 9/19/21 3:05 PM | Arizona Cardinals | Minnesota Vikings | 34-33 | 3 - 10 - 6 |
| 9/19/21 3:25 PM | 9/19/21 3:25 PM | Los Angeles Chargers | Dallas Cowboys | 17-20 | 5 - 10 - 3 |
| 9/19/21 3:25 PM | 9/19/21 3:25 PM | Seattle Seahawks | Tennessee Titans | 30-33OT | 3 - 10 - 8 |
| 9/19/21 7:20 PM | 9/19/21 7:20 PM | Baltimore Ravens | Kansas City Chiefs | 36-35 | 8 - 10 - 3 |
| 9/20/21 7:15 PM | 9/20/21 7:15 PM | Green Bay Packers | Detroit Lions | 35-17 | 3 - 10 - 8 |