Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/22/22 7:15 PM | 9/22/22 7:15 PM | Cleveland Browns | Pittsburgh Steelers | 29-17 | 4 - 10 - 5 |
| 9/25/22 12:00 PM | 9/25/22 12:00 PM | Washington Commanders | Philadelphia Eagles | 8-24 | 7 - 10 - 3 |
| 9/25/22 12:00 PM | 9/25/22 12:00 PM | Tennessee Titans | Las Vegas Raiders | 24-22 | 5 - 10 - 4 |
| 9/25/22 12:00 PM | 9/25/22 12:00 PM | New England Patriots | Baltimore Ravens | 26-37 | 5 - 10 - 4 |
| 9/25/22 12:00 PM | 9/25/22 12:00 PM | New York Jets | Cincinnati Bengals | 12-27 | 7 - 10 - 3 |
| 9/25/22 12:00 PM | 9/25/22 12:00 PM | Carolina Panthers | New Orleans Saints | 22-14 | 6 - 10 - 3 |
| 9/25/22 12:00 PM | 9/25/22 12:00 PM | Minnesota Vikings | Detroit Lions | 28-24 | 3 - 10 - 5 |
| 9/25/22 12:00 PM | 9/25/22 12:00 PM | Miami Dolphins | Buffalo Bills | 21-19 | 6 - 10 - 3 |
| 9/25/22 12:00 PM | 9/25/22 12:00 PM | Indianapolis Colts | Kansas City Chiefs | 20-17 | 10 - 10 - 3 |
| 9/25/22 12:00 PM | 9/25/22 12:00 PM | Chicago Bears | Houston Texans | 23-20 | 3 - 10 - 8 |
| 9/25/22 3:05 PM | 9/25/22 3:05 PM | Los Angeles Chargers | Jacksonville Jaguars | 10-38 | 3 - 10 - 10 |
| 9/25/22 3:25 PM | 9/25/22 3:25 PM | Tampa Bay Buccaneers | Green Bay Packers | 12-14 | 4 - 10 - 5 |
| 9/25/22 3:25 PM | 9/25/22 3:25 PM | Seattle Seahawks | Atlanta Falcons | 23-27 | 4 - 10 - 4 |
| 9/25/22 3:25 PM | 9/25/22 3:25 PM | Arizona Cardinals | Los Angeles Rams | 12-20 | 7 - 10 - 3 |
| 9/25/22 7:20 PM | 9/25/22 7:20 PM | Denver Broncos | San Francisco 49ers | 11-10 | 5 - 10 - 4 |
| 9/26/22 7:15 PM | 9/26/22 7:15 PM | New York Giants | Dallas Cowboys | 16-23 | 4 - 10 - 4 |