Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/30/21 7:20 PM | 9/30/21 7:20 PM | Cincinnati Bengals | Jacksonville Jaguars | 24-21 | 3 - 10 - 10 |
| 10/3/21 12:00 PM | 10/3/21 12:00 PM | Atlanta Falcons | Washington Football Team | 30-34 | 4 - 10 - 4 |
| 10/3/21 12:00 PM | 10/3/21 12:00 PM | Miami Dolphins | Indianapolis Colts | 17-27 | 4 - 10 - 4 |
| 10/3/21 12:00 PM | 10/3/21 12:00 PM | Buffalo Bills | Houston Texans | 40-0 | 3 - 10 - 10 |
| 10/3/21 12:00 PM | 10/3/21 12:00 PM | Chicago Bears | Detroit Lions | 24-14 | 4 - 10 - 5 |
| 10/3/21 12:00 PM | 10/3/21 12:00 PM | Minnesota Vikings | Cleveland Browns | 7-14 | 5 - 10 - 4 |
| 10/3/21 12:00 PM | 10/3/21 12:00 PM | New Orleans Saints | New York Giants | 21-27OT | 3 - 10 - 10 |
| 10/3/21 12:00 PM | 10/3/21 12:00 PM | Dallas Cowboys | Carolina Panthers | 36-28 | 3 - 10 - 5 |
| 10/3/21 12:00 PM | 10/3/21 12:00 PM | Philadelphia Eagles | Kansas City Chiefs | 30-42 | 10 - 10 - 3 |
| 10/3/21 12:00 PM | 10/3/21 12:00 PM | New York Jets | Tennessee Titans | 27-24OT | 10 - 10 - 3 |
| 10/3/21 3:05 PM | 10/3/21 3:05 PM | Los Angeles Rams | Arizona Cardinals | 20-37 | 3 - 10 - 9 |
| 10/3/21 3:05 PM | 10/3/21 3:05 PM | San Francisco 49ers | Seattle Seahawks | 21-28 | 4 - 10 - 4 |
| 10/3/21 3:25 PM | 10/3/21 3:25 PM | Denver Broncos | Baltimore Ravens | 7-23 | 6 - 10 - 3 |
| 10/3/21 3:25 PM | 10/3/21 3:25 PM | Green Bay Packers | Pittsburgh Steelers | 27-17 | 3 - 10 - 9 |
| 10/3/21 7:20 PM | 10/3/21 7:20 PM | New England Patriots | Tampa Bay Buccaneers | 17-19 | 10 - 10 - 3 |
| 10/4/21 7:15 PM | 10/4/21 7:15 PM | Los Angeles Chargers | Las Vegas Raiders | 28-14 | 4 - 10 - 4 |