Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/14/21 7:20 PM | 10/14/21 7:20 PM | Philadelphia Eagles | Tampa Bay Buccaneers | 22-28 | 10 - 10 - 3 |
| 10/17/21 8:30 AM | 10/17/21 8:30 AM | Jacksonville Jaguars | Miami Dolphins | 23-20 | 4 - 10 - 4 |
| 10/17/21 12:00 PM | 10/17/21 12:00 PM | Carolina Panthers | Minnesota Vikings | 28-34OT | 4 - 10 - 4 |
| 10/17/21 12:00 PM | 10/17/21 12:00 PM | Baltimore Ravens | Los Angeles Chargers | 34-6 | 4 - 10 - 4 |
| 10/17/21 12:00 PM | 10/17/21 12:00 PM | Chicago Bears | Green Bay Packers | 14-24 | 9 - 10 - 3 |
| 10/17/21 12:00 PM | 10/17/21 12:00 PM | Detroit Lions | Cincinnati Bengals | 11-34 | 7 - 10 - 3 |
| 10/17/21 12:00 PM | 10/17/21 12:00 PM | Indianapolis Colts | Houston Texans | 31-3 | 3 - 10 - 10 |
| 10/17/21 12:00 PM | 10/17/21 12:00 PM | New York Giants | Los Angeles Rams | 11-38 | 10 - 10 - 3 |
| 10/17/21 12:00 PM | 10/17/21 12:00 PM | Washington Football Team | Kansas City Chiefs | 13-31 | 10 - 10 - 3 |
| 10/17/21 3:05 PM | 10/17/21 3:05 PM | Cleveland Browns | Arizona Cardinals | 14-37 | 4 - 10 - 4 |
| 10/17/21 3:25 PM | 10/17/21 3:25 PM | New England Patriots | Dallas Cowboys | 29-35OT | 7 - 10 - 3 |
| 10/17/21 3:25 PM | 10/17/21 3:25 PM | Denver Broncos | Las Vegas Raiders | 24-34 | 4 - 10 - 5 |
| 10/17/21 7:20 PM | 10/17/21 7:20 PM | Pittsburgh Steelers | Seattle Seahawks | 23-20OT | 4 - 10 - 5 |
| 10/18/21 7:15 PM | 10/18/21 7:15 PM | Tennessee Titans | Buffalo Bills | 34-31 | 10 - 10 - 3 |