Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/21/21 7:20 PM | 10/21/21 7:20 PM | Cleveland Browns | Denver Broncos | 17-14 | 3 - 10 - 6 |
| 10/24/21 12:00 PM | 10/24/21 12:00 PM | Baltimore Ravens | Cincinnati Bengals | 17-41 | 3 - 10 - 10 |
| 10/24/21 12:00 PM | 10/24/21 12:00 PM | Miami Dolphins | Atlanta Falcons | 28-30 | 5 - 10 - 4 |
| 10/24/21 12:00 PM | 10/24/21 12:00 PM | Green Bay Packers | Washington Football Team | 24-10 | 3 - 10 - 10 |
| 10/24/21 12:00 PM | 10/24/21 12:00 PM | Tennessee Titans | Kansas City Chiefs | 27-3 | 4 - 10 - 4 |
| 10/24/21 12:00 PM | 10/24/21 12:00 PM | New England Patriots | New York Jets | 54-13 | 3 - 10 - 10 |
| 10/24/21 12:00 PM | 10/24/21 12:00 PM | New York Giants | Carolina Panthers | 25-3 | 7 - 10 - 3 |
| 10/24/21 3:05 PM | 10/24/21 3:05 PM | Las Vegas Raiders | Philadelphia Eagles | 33-22 | 3 - 10 - 8 |
| 10/24/21 3:05 PM | 10/24/21 3:05 PM | Los Angeles Rams | Detroit Lions | 28-19 | 3 - 10 - 10 |
| 10/24/21 3:25 PM | 10/24/21 3:25 PM | Tampa Bay Buccaneers | Chicago Bears | 38-3 | 3 - 10 - 10 |
| 10/24/21 3:25 PM | 10/24/21 3:25 PM | Arizona Cardinals | Houston Texans | 31-5 | 3 - 10 - 10 |
| 10/24/21 7:20 PM | 10/24/21 7:20 PM | San Francisco 49ers | Indianapolis Colts | 18-30 | 4 - 10 - 4 |
| 10/25/21 7:15 PM | 10/25/21 7:15 PM | Seattle Seahawks | New Orleans Saints | 10-13 | 6 - 10 - 3 |