Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/4/21 7:20 PM | 11/4/21 7:20 PM | Indianapolis Colts | New York Jets | 45-30 | 3 - 10 - 10 |
| 11/7/21 12:00 PM | 11/7/21 12:00 PM | New York Giants | Las Vegas Raiders | 23-16 | 8 - 10 - 3 |
| 11/7/21 12:00 PM | 11/7/21 12:00 PM | Miami Dolphins | Houston Texans | 17-9 | 3 - 10 - 6 |
| 11/7/21 12:00 PM | 11/7/21 12:00 PM | Jacksonville Jaguars | Buffalo Bills | 9-6 | 10 - 10 - 3 |
| 11/7/21 12:00 PM | 11/7/21 12:00 PM | Cincinnati Bengals | Cleveland Browns | 16-41 | 4 - 10 - 5 |
| 11/7/21 12:00 PM | 11/7/21 12:00 PM | Baltimore Ravens | Minnesota Vikings | 34-31OT | 3 - 10 - 10 |
| 11/7/21 12:00 PM | 11/7/21 12:00 PM | Carolina Panthers | New England Patriots | 6-24 | 5 - 10 - 4 |
| 11/7/21 12:00 PM | 11/7/21 12:00 PM | Dallas Cowboys | Denver Broncos | 16-30 | 3 - 10 - 10 |
| 11/7/21 12:00 PM | 11/7/21 12:00 PM | New Orleans Saints | Atlanta Falcons | 25-27 | 3 - 10 - 10 |
| 11/7/21 3:05 PM | 11/7/21 3:05 PM | Philadelphia Eagles | Los Angeles Chargers | 24-27 | 6 - 10 - 3 |
| 11/7/21 3:25 PM | 11/7/21 3:25 PM | San Francisco 49ers | Arizona Cardinals | 17-31 | 6 - 10 - 3 |
| 11/7/21 3:25 PM | 11/7/21 3:25 PM | Kansas City Chiefs | Green Bay Packers | 13-7 | 4 - 10 - 4 |
| 11/7/21 7:20 PM | 11/7/21 7:20 PM | Los Angeles Rams | Tennessee Titans | 16-28 | 3 - 10 - 9 |
| 11/8/21 7:15 PM | 11/8/21 7:15 PM | Pittsburgh Steelers | Chicago Bears | 29-27 | 3 - 10 - 10 |