| Date | Home | Away | Result |
|---|---|---|---|
| 10/28/22 1:45 PM | KRC Genk | KV Mechelen | 3-1 |
| 10/29/22 9:00 AM | SV Zulte-Waregem | Standard Liège | 0-3 |
| 10/29/22 11:15 AM | KVC Westerlo | Sint-Truidense VV | 2-3 |
| 10/29/22 11:15 AM | KV Kortrijk | KSV Cercle Brügge | 1-1 |
| 10/29/22 1:45 PM | Club Brugge | KV Oostende | 4-2 |
| 10/30/22 7:30 AM | RSC Anderlecht | KAS Eupen | 4-2 |
| 10/30/22 10:00 AM | RFC Seraing | Royale Union Saint-Gilloise | 1-2 |
| 10/30/22 12:30 PM | OH Leuven | KAA Gent | 1-1 |
| 10/30/22 3:00 PM | Sporting Charleroi | Royal Antwerp FC | 1-0 |