| Date | Home | Away | Result |
|---|---|---|---|
| 11/4/22 2:45 PM | KRC Genk | Sporting Charleroi | 4-1 |
| 11/5/22 10:00 AM | KV Mechelen | SV Zulte-Waregem | 2-2 |
| 11/5/22 12:15 PM | KSV Cercle Brügge | OH Leuven | 2-1 |
| 11/5/22 12:15 PM | RFC Seraing | Sint-Truidense VV | 1-2 |
| 11/5/22 2:45 PM | KAS Eupen | Standard Liège | 2-0 |
| 11/6/22 6:30 AM | KAA Gent | Club Brugge | 2-0 |
| 11/6/22 9:00 AM | Royale Union Saint-Gilloise | KVC Westerlo | 1-1 |
| 11/6/22 11:30 AM | Royal Antwerp FC | RSC Anderlecht | 0-0 |
| 11/6/22 2:00 PM | KV Oostende | KV Kortrijk | 3-1 |