| Date | Home | Away | Result |
|---|---|---|---|
| 8/13/21 1:45 PM | Sporting Charleroi | Royal Antwerp FC | 1-1 |
| 8/14/21 9:15 AM | Royale Union Saint-Gilloise | KV Kortrijk | 2-0 |
| 8/14/21 11:30 AM | KAS Eupen | Sint-Truidense VV | 2-1 |
| 8/14/21 11:30 AM | RFC Seraing | KV Oostende | 2-3 |
| 8/14/21 1:45 PM | KRC Genk | OH Leuven | 4-0 |
| 8/15/21 6:30 AM | K. Beerschot V.A. | Standard Liège | 0-1 |
| 8/15/21 9:00 AM | KAA Gent | KV Mechelen | 2-0 |
| 8/15/21 11:30 AM | KSV Cercle Brügge | RSC Anderlecht | 1-2 |
| 8/15/21 2:00 PM | SV Zulte-Waregem | Club Brugge | 0-4 |