| Date | Home | Away | Result |
|---|---|---|---|
| 11/5/21 2:45 PM | OH Leuven | KV Oostende | 1-0 |
| 11/6/21 10:15 AM | KAS Eupen | SV Zulte-Waregem | 1-1 |
| 11/6/21 12:30 PM | KV Mechelen | Sint-Truidense VV | 0-1 |
| 11/6/21 12:30 PM | KV Kortrijk | K. Beerschot V.A. | 1-1 |
| 11/6/21 2:45 PM | Royale Union Saint-Gilloise | Sporting Charleroi | 4-0 |
| 11/7/21 6:30 AM | Club Brugge | Standard Liège | 2-2 |
| 11/7/21 9:00 AM | RFC Seraing | KAA Gent | 0-0 |
| 11/7/21 11:30 AM | Royal Antwerp FC | RSC Anderlecht | 2-0 |
| 11/7/21 2:00 PM | KRC Genk | KSV Cercle Brügge | 1-1 |