| Date | Home | Away | Result |
|---|---|---|---|
| 1/13/23 1:45 PM | KVC Westerlo | OH Leuven | 1-2 |
| 1/14/23 9:00 AM | RFC Seraing | Standard Liège | 1-1 |
| 1/14/23 11:15 AM | KAS Eupen | Sint-Truidense VV | 0-2 |
| 1/14/23 11:15 AM | KV Mechelen | KV Oostende | 2-1 |
| 1/14/23 1:45 PM | KRC Genk | SV Zulte-Waregem | 1-0 |
| 1/15/23 6:30 AM | Club Brugge | RSC Anderlecht | 1-1 |
| 1/15/23 9:00 AM | KAA Gent | KV Kortrijk | 2-1 |
| 1/15/23 11:30 AM | Royale Union Saint-Gilloise | Royal Antwerp FC | 2-0 |
| 1/15/23 2:00 PM | Sporting Charleroi | KSV Cercle Brügge | 2-1 |