| Date | Home | Away | Result |
|---|---|---|---|
| 10/1/21 1:45 PM | KV Mechelen | Standard Liège | 3-1 |
| 10/2/21 9:15 AM | KV Kortrijk | Sporting Charleroi | 2-2 |
| 10/2/21 11:30 AM | KSV Cercle Brügge | Royale Union Saint-Gilloise | 0-3 |
| 10/2/21 11:30 AM | Sint-Truidense VV | KV Oostende | 1-1 |
| 10/2/21 1:45 PM | OH Leuven | K. Beerschot V.A. | 0-0 |
| 10/3/21 6:30 AM | RSC Anderlecht | Club Brugge | 1-1 |
| 10/3/21 9:00 AM | RFC Seraing | SV Zulte-Waregem | 5-1 |
| 10/3/21 11:30 AM | Royal Antwerp FC | KAA Gent | 1-0 |
| 10/3/21 2:00 PM | KAS Eupen | KRC Genk | 3-2 |