| Date | Home | Away | Result |
|---|---|---|---|
| 9/16/22 1:45 PM | Royal Antwerp FC | RFC Seraing | 2-1 |
| 9/17/22 9:00 AM | KV Mechelen | OH Leuven | 0-0 |
| 9/17/22 11:15 AM | KSV Cercle Brügge | KV Oostende | 2-2 |
| 9/17/22 11:15 AM | SV Zulte-Waregem | Sint-Truidense VV | 0-3 |
| 9/17/22 1:45 PM | Sporting Charleroi | KVC Westerlo | 2-3 |
| 9/18/22 6:30 AM | KRC Genk | KAA Gent | 1-0 |
| 9/18/22 9:00 AM | KAS Eupen | Royale Union Saint-Gilloise | 1-2 |
| 9/18/22 11:30 AM | Standard Liège | Club Brugge | 3-0 |
| 9/18/22 2:00 PM | RSC Anderlecht | KV Kortrijk | 4-1 |