| Date | Home | Away | Result |
|---|---|---|---|
| 10/15/21 1:45 PM | Club Brugge | KV Kortrijk | 2-0 |
| 10/16/21 9:15 AM | Royale Union Saint-Gilloise | RFC Seraing | 4-2 |
| 10/16/21 11:30 AM | KV Oostende | KSV Cercle Brügge | 2-1 |
| 10/16/21 11:30 AM | SV Zulte-Waregem | Royal Antwerp FC | 2-1 |
| 10/16/21 1:45 PM | Standard Liège | OH Leuven | 2-2 |
| 10/17/21 6:30 AM | Sint-Truidense VV | RSC Anderlecht | 2-2 |
| 10/17/21 9:00 AM | K. Beerschot V.A. | KV Mechelen | 0-1 |
| 10/17/21 11:30 AM | Sporting Charleroi | KRC Genk | 2-0 |
| 10/17/21 2:00 PM | KAA Gent | KAS Eupen | 2-0 |