| Date | Home | Away | Result |
|---|---|---|---|
| 12/3/21 1:45 PM | Sint-Truidense VV | Royale Union Saint-Gilloise | 1-2 |
| 12/4/21 9:15 AM | OH Leuven | KAA Gent | 0-1 |
| 12/4/21 11:30 AM | KV Kortrijk | KSV Cercle Brügge | 0-2 |
| 12/4/21 11:30 AM | KV Oostende | KAS Eupen | 2-1 |
| 12/4/21 1:45 PM | Club Brugge | RFC Seraing | 3-2 |
| 12/5/21 6:30 AM | K. Beerschot V.A. | Royal Antwerp FC | 0-1 |
| 12/5/21 9:00 AM | RSC Anderlecht | SV Zulte-Waregem | 3-2 |
| 12/5/21 11:30 AM | Standard Liège | Sporting Charleroi | 0-3 |
| 12/5/21 2:00 PM | KV Mechelen | KRC Genk | 1-1 |