| Date | Home | Away | Result |
|---|---|---|---|
| 12/17/21 1:45 PM | RFC Seraing | KV Kortrijk | 0-2 |
| 12/18/21 9:15 AM | K. Beerschot V.A. | KV Oostende | 0-2 |
| 12/18/21 11:30 AM | SV Zulte-Waregem | KV Mechelen | 3-2 |
| 12/18/21 11:30 AM | Royale Union Saint-Gilloise | KSV Cercle Brügge | 3-2 |
| 12/18/21 1:45 PM | KAA Gent | Sint-Truidense VV | 2-1 |
| 12/19/21 6:30 AM | Club Brugge | RSC Anderlecht | 2-2 |
| 12/19/21 9:00 AM | KAS Eupen | Sporting Charleroi | 0-4 |
| 12/19/21 11:30 AM | KRC Genk | Royal Antwerp FC | 1-1 |
| 12/19/21 2:00 PM | OH Leuven | Standard Liège | 2-1 |